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Multi-Segmented Vaginal Ring with
Trans-Vaginal Delivery
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Drug standard = subcutaneous delivery (IV or IM)
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Alternate Routes of Delivery = Oral, Pulmonary, Nasal, Buccal, Transdermal, Vaginal, Ocular, Aural
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Vaginal Advantages over Alt. Routes of Delivery
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Permeability .5 - 20x
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Bioavailability 20 - 80x (30-85% sub q)
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Contact Time -w/o adhesive 15 - 40x with adhesive 4 - 7x
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Half-life 1 - 2x
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Large molecules (Insulin, GnRH) demonstrated to cross vaginal mucosa and have physiological effect
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Polymers as large as 2500KD move across vaginal mucosa in animal models
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